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"In the same vein, the 1 Piece of Rubbish campaign, launched by British expatriate Eddie Platt in the southern French city of Marseille has won cyber fans around the world from Buenos Aires to New York. But I think it does make them start to reflect on what we&PVC injection molding machine Manufacturers39;re doing," he says..He, himself, began doing so and has been picking up litter every day since. Since last year, they have been spreading their philosophy online."Last month, the Slovak Wastebusters launched a website to further spread the word.4 million inhabitants produced about 321 kilos of household rubbish in 2014."Maybe it'll stop them from tossing their next beer can or bubble gum wrapper."They don't have to plan anything or specifically go somewhere to pick up trash," he says.

He's shown me that it doesn't take any extraordinary effort to pick up trash," she says.Their idea is simple: anyone who picks up at least one item of trash a day qualifies as a Wastebuster.Participants post selfies on a social network each time they pick up a piece of litter and put it in the rubbish bin.Their main piece of advice, however, is one that may sound like a no-brainer but makes a world of difference: all it takes is one piece of garbage a day."I realised that if fewer people complained and instead each picked up one piece of garbage off the ground and binned it, our city would not be as polluted," he tells AFP."You can do it on your way home, on the way to the cinema or while waiting for the bus." Anywhere, anytime Slovakians rank among the least worst offenders for piling up rubbish in the European Union, according to Eurostat figures, # which showed each of the country's 5.

"For us time flew by, for them it went slowly," he adds, picking up yet another plastic bottle on a weekend stroll around a lake.Boss on boardTheir crusade began two years ago, when Rastislav was living in the capital Bratislava and overheard his neighbours complain about litter on the block. You drop litter, I pick it up."When people see us picking up trash, they never join in.

It's people's mentalities that should change."No one joined in."Before I met Rasto, I thought garbage on the ground didn't concern me.She says they do not stop at one piece of trash a day.Their Facebook page now has thousands of followers, who post stories and photos of cleaning up the streets and countryside."One person's a litterer, another's a cleaner. He also encouraged his wife, Veronika, 30, to join in. No instant results but he is optimistic about change down the line.Rovinka (Slovakia): Slovak financial analyst Rastislav Krul and his wife once waited out an hour-long traffic jam by picking up several bags worth of rubbish around a rest area off the motorway.

"I took the first step by no longer buying bottled water for work."Now it's become a part of me," she adds, pointing to the plastic bottles, beer cans, empty cigarette cartons and sweet wrappers poking out of the grass.How much of it ends up thrown out on to the streets is hard to say, but the couple feel they still have plenty to do and say the Wastebusters project is a good option for those who hate organised cleaning. Then if we see something we can just stop, pick it up and walk on."When we go for a walk, bike ride or hike, we usually take some gloves and bags with us."Rastislav has even managed to win over his boss: "When he's out with his kids, they sometimes pick up trash. Instead, I brought a glass water bottle that I fill up and use," says Rastislav. Most of the comments are positive. People just watched us from their cars," recalls the 30-year-old, who has launched an anti-litter campaign from his western village of Rovinka."Laws and fines don't solve anything.Rastislav says setting an example is like a long-distance run. They also plan to provide tips and tricks on how to reduce waste

The researchers also created two smart objects — a detergent bottle with an attached flowmeter to track the amount of remaining detergent and a test tube holder that can measure the amount of liquid. The team developed an anemometer that measures wind speed, and attached it to a gear.The signal transmission is dependent on the speed of the wind, the faster the gear spins and the more rapid signals are transmitted.

Researchers at the University of Washington have developed a new way for 3D-printed plastic objects to pass on information through Wi-Fi eliminating the need of batteries or electronics. When the gear spins, the teeth connect with an antenna incorporated within the object and the antenna then reflects ambient Wi-Fi signal, which is then decoded by a Wi-Fi receiver.This team of researchers is making their China PVC injection molding machine 3D-printed models available for public so everyone can utilise the new object in their households.

They demonstrated how it can be done with commercially available plastics and Wi-Fi receivers.. "Our goal was to create something that just comes out of your 3D printer at home and can send useful information to other devices," says Vikram Iyer, a graduate student on the project. "But the big challenge is how do you communicate wirelessly with WiFi using only plastic? That's something that no one has been able to do before.Lastly, the team developed a way to print iron into 3D objects, which when read using a magnetometer through a smart device, can be used to transmit information about that specific object.

"It looks like a regular 3D-printed object but there's invisible information inside that can be read with your smartphone," said Justin Chan, another student on the project."To make this thing work, the team assembled things like 3D-printed gears, switches and springs that could be used translate motion into antenna-transmitted information.Additionally, three widgets — a button, a knob and a slider, that work similarly and can be used to connect with other smart devices. The team also deployed a scale and a flowmeter to measure the speed of the water

On running down to check the package he made the shocking discovery. She will be prosecuted after all evidence has been gathered.Investigations are underway.20-year-old Netchanok Nokyungton, was apparently devastated when her cheating 40-year-old lover from South Korea found out she was pregnant and left her. However, when she revealed to him that she was pregnant; he wanted nothing to do with her and left to go back to his wife.

A horrified workman who was present at the fourth floor told police that he saw a large object fall past his window and hit the ground at around 5pm. Subsequently, she put the baby in a plastic bag and threw it out of the window and it died.She had previously shown police where she had claimed to have thrown the tot out the window on Tuesday, just moments after it was born.He went on to add that Nokyungtong gave birth in bathroom where blood was found on the floor.Police arrived and found the bloodied child wrapped in a green plastic bag with the umbilical cord still attached.

 She was heartbroken because he returned to his family.The Police Colonel investigating stated that the crime was brutal and the baby was born in a healthy condition.Police say that according to the woman she did not have money to support the child.Apparently Nokyungtong did not have grief for what had happened.

According to Police Colonel Apichai Khemphet, head of the Pattaya Polce, Nokyungtong admitted to throwing the HXH 160 baby out of her high-rise window in an apartment block in Pattaya.Apparently, the boyfriend is a married foreigner from South Korea who did not want to stay with her. She said she was shocked and not ready for the birth.In a shocking incident, a spurned mum threw here newborn baby from a 17th floor window because, her married boyfriend had left her to return to his family. She has since been taken to hospital to be checked but is expected to be prosecuted..The revelation has been made by the police.'According to Nokyungtong she had been in a relationship with her boyfriend "Kim", aged 40, from South Korea for two years

There is a thin line between disliking and the disorder. After counseling we get to know if the person has BDD,” said Dr Mundada. At least 68 per cent of the men and 79 per cent of women are dissatisfied with their appearances. And most importantly, patients don’t even understand that they are suffering from such a disorder, said Dr Tank. The study was done on 700 Mumbaikars belonging to the age group of 20 to 25 by the Podar Institute of Education in Santa Cruz. BDD is a mental disorder wherein a person becomes obsessed with the defects in their appearance and starts running from one doctor to another to correct a particular feature.

“We hardly get 10 such cases of BDD out of the 100 who come to us for counselling. This further aggravates their condition as their inner strength gets dependent on the number of likes or comments they receive from their virtual friends,” said Dr Tank.. “A patient when after several plastic surgeries if still complains about his/her appearance, the surgeon becomes suspicious and sends the patient to a psychiatrist for check up.

No one is perfect, we all have some defects or the other, but not every one becomes obsessed with changing their appearances,” said Dr Parul Tank, consultant psychiatrist and therapist, Fortis Hospital, Mulund.Mumbai may be known for its glitz and glamour, but a study shows that 3/4th of its youth are not happy with the way they look. However, tellingly, the study also indicated that a significant number of youngsters had shown symptoms of Body Dysmorphic Disorder (BDD). The report also stated that 51 per cent of the surveyed use social media at least five hours a day.

Some 38 per cent accepted that they joined social media to make friends as they lack friends in real life and it helped in boosting their self-esteem.Commenting on the disorder, Dr Sagar Mundada, psychiatrist at GT hospital, said such patients suffer from too much of mental agony as they keep seeking perfection. However he said that such cases were rare. But when the disliking turns into an obsession, it becomes China double color injection molding machine a disorder,” said Dr Tank. Many youths with low self-esteem suffer from anxiety and depend on social media to gain their self-confidences.

At least 58 per cent of women said that they had considered cosmetic surgery to improve their looks. To attain their desired looks, they don’t even mind going under the knife for plastic surgeries, the survey said.“With the growing usage of social media, such cases have become common in metros. “The disorder is characterised by an unhealthy obsession with a perceived physical defect, ranging from skin colour to body shape

As we are changing into an international destination with a developed sense of urbanity and cosmopolitan attitudes to life, this idea of protecting and caring about only the immediate family has to change. Our concerns have to turn towards emphasising health and the message has to be coded in our brain at a deeper level. We need to have stricter punitive laws around littering.While we talk a great story when it comes to keeping our city clean, and the conversation on the need for better management of waste has progressed, the needle has barely shifted on the outcome. Most urban homes are clean spaces and yet those very same people, who are so particular about keeping their homes clean, think nothing of littering the city.As such we are a fastidious and house-proud people. For instance, if we need to realize that it is important to keep our surroundings germ free as it will lead to a greater sense of health and well-being that goes beyond the home. This is part of the reason why we are struggling to change the approach to waste and it reflects our attitude towards waste.

It is that sense of shame that is encoded into our belief systems that makes us automatically relegate this problem of keeping the city clean to someone else, of lesser social ranking, caste or gender. If those latent needs and desires are tapped into, it may result in a sense of change towards public sanitation.If we commit to recycling our waste and stop viewing it as useless, that is one step closer to the solution. We will be okay wading through a street that is filled with muck to buy our packaged and super hygienic products.I was quite struck by this cute advertisement on the TV the other night, Varun Dhawan and Alia Bhatt take a trip to the moon, and as soon as they land, Alia litters the planet with a candy wrapper. These mindsets need to change. The Swachchh Bharat Mission has to translate beyond the photo-op of the Bollywood star or politician posing with a broom. It has been offered as an explanation that it is our fear of scarcity as a developing nation has led us to be more concerned about our individual or immediate wellbeing rather than our extended surroundings.

There may be times when we actually have to wield it and there should be wholesale PET injection molding machine no sense of shame associated with that act. Our cities are still littered with urban waste, plastic bags, the omnipresent gutka packet, the thermocol and Styrofoam cups and plates that are left over after any Bhandara or mela, the unseparated waste, often lies uncleared, swarming with flies and being feasted upon by cows, dogs and other urban scavengers. We are yet to see an attitudinal change where people adopt the ideas propagated on large shiny billboards that dot our metropolises.

The writer is the chairperson of the AICC grievance cell. Varun scolds her and tells her to pick it up, saying something to the effect that we have already littered one planet with urban waste, do you want to ruin the moon too? Although I wish the gender roles in this Ad were reversed, it is a sentiment I hold dear to my heart, because I firmly believe that while we need a lot of infrastructure around waste management in cities, what we need more is for people’s attitude to change towards public littering. We have instances and examples from around the world.If we were to use the technology available to us like WhatsApp and various other social media to spread this idea of taking pride in a clean city, it will solidify and lead to a sense of overall ‘need’ for cleanliness. Our malls are clean, but our streets are not? We need to lead by example and if our public areas are kept clean, then we automatically as people get a subliminal message that it is our job to keep it that way. We need to develop a larger sense of self that extends to our pride and concern for our city..Moreover, no one seems to think its their problem and we are quick to blame sanitary department rather than look at our responsibility to reduce production and distribution of urban waste. My contention is that a greater sense of ownership of public spaces is what will change people’s attitude towards keeping our city clean.Dirt is impure and hence it corrupts us to deal with any of it.

The caste stigma around picking up the broom has not faded, and people still blame the municipal worker for the state of their city. We will ignore the overflowing wastebasket at the hospital if the syringe is new and taken out of a plastic packet.The good old Pavlovian learning method often works wonders.There has to be change on many levels, from the Central government, to the State, to the local urban bodies and committees managing a closed gate society to finally the common person on the street.Going beyond the crumbling waste management infrastructure, our people have to change their mindset. It is not just cities from developed nations like Calgary in Canada or Adelaide in Australia, but Kigali in developing Rwanda, that has transformed and cleaned “itself” in a relatively short span of time.With punishment comes a reward, if we have certain public drives highlighting and praising the good outcome of cleanliness, then it will also translate into a better approach towards keeping our city clean.It will evoke a sense of pride in people and this often leads to people moving beyond the symbolic idea of pride into an actualization of the emotion. Our competitive streak needs to go beyond just our own well-being to a sense of whose neighbourhood is the cleanest? The multiple stakeholders in this problem of our mindset towards waste needs to be changed. It is a strategy where the sense of ownership extends beyond our selves and our homes to the common goods and spaces. Fines and other punishments that insight a sense of fear in people does translate into a better regard for cleanliness

Cover and let stand for 10 to 12 minutes.MethodIn a medium bowl, beat together cream cheese and butter until smooth.

Remove eggs from hot water and let cool.Cut each egg in half lengthwise, remove the yolks, and place the yolks in a bowl with the mustard, mayonnaise, Worcester-shire sauce, hot pepper sauce, and salt and pepper.Mash the yolks, and stir the mixture until smooth and thoroughly combined.

Mix in confectioners' sugar, brown sugar and vanilla.Chocolate chip cheese ballIngredients1 (8 ounce) package cream cheese softened, 1/2 cup China SP smart power Injection Molding Machine Factory butter softened, 3/4 cup confectioners’ sugar, 2 tablespoons brown sugar, 1/4 teaspoon vanilla extract, 3/4 cup miniature semi-sweet chocolate chips, 3/4 cup finely chopped pecans.

Wrap with plastic, and chill in the refrigerator for 1 hour.Fill each egg half with the devilled yolk mixture, using a spoon, piping bag, or a sturdy plastic bag with a corner cut off.It’s Halloween! Here are some spooked up bites you can rustle up for that mad costume party at home Ingredients12 eggs, 1 1/2 tablespoons Dijon mustard, 1 1/2 tablespoons mayonnaise, 1/2 teaspoon Worcestershire sauce, 1/2 teaspoon hot pepper sauce or to taste, 1 pinch salt and black pepper, 1/4 teaspoon ground paprika, for dusting (divided), 1 (6 ounce) can black olives, drained and cut in half horizontally MethodPlace eggs in a saucepan with a lid, pour in water to cover, bring to a boil, and remove from the heat.. Refrigerate until chilled, 20 to 30 minutes, and serve cold. Cover, and chill in the refrigerator for 2 hours. Dust each egg with a pinch of paprika, and place an olive half, round side up, in the center of each. Peel the eggs.Roll the cheese ball in finely chopped pecans before serving.Shape chilled cream cheese mixture into a ball. Stir in chocolate chips

” he adds. They are seen as normal workers, busy doing their jobs, workers who want to be considered equal to others, recognised for their work and by society., the materials they extract and transform — plastic, cardboard, metal, glass, fabric, etc.”“The photographs show the clothes that protect their bodies — rags, strips of cloth, or even plastic bags, and also the gloves and uniforms worn by those whose work is better recognised. Despite its innocence and naivete, the drawing is very precise: it represents the weighing machine on the right, the cycle on the left, the landfill in the background and the father holding a bag in the back. I’ve been particularly touched by how Anjali, 10 years old, described her father as a super hero because he goes everyday to the top of the mountain of waste to collect recyclable material that he then sells to make a living.”His experience with the kids of waste workers was especially close to his heart. The photographs in the exhibition document the conditions waste workers live and work in: open landfills, waste containers and public spaces from where they collect waste, as well as garbage dumps, warehouse, factories, markets and recycling workshops, where waste is reclassified and transformed into a profitable resource. The biffins in Paris, cartoneros in Argentina, catadores in Brazil, pepenadores in Mexico, waste pickers in India, zabbâlîn in Egypt, bouâra in Morocco, and topla?c?lar in Turkey, all these men, women and sometimes children and the old, pushed to the fringes of the labour market and often living on the margins of society, are making a profit from city dwellers’ refuse. Sometime, people can be suspicious, and it’s understandable, but most of the time, once they understood why we are interested in their life, they are quite welcoming and it’s easy to converse with them, drink tea, to talk about our respective lives.”Working on the project also involved tackling several plastic injection molding machine price challenges.”Waste workers are discriminated against not just in India but across the world, admits Rémi, adding, “The discrimination is actually similar all around the world and this is by no means a recent phenomenon.Working on the project and his interacting with the people was an enriching experience for Rémi.

I finally paid for it.The city of waste is a world in itself, a parallel city we avoid seeing.. With the work they do to extract a variety of materials, these waste workers earn a generally modest living, and provide a real service to the city and its inhabitants, doing away with a part of their waste.As part of Habitat Photosphere, India Habitat Centre’s yearlong photography festival on sustainable development curated by Dr Alka Pande, six French photographers are showcasing 42 photographs that delve into the role of waste workers across the world in a show titled ‘The City of Waste’ in the capital. also reveal the diversity of the practices and the ingenuity the recyclers bring to their work.

“The biggest challenge was to bargain with waste traders to be able to install the ‘tower of waste’ in the middle of the photographs that we had built. The techniques and tools they use — baskets, hooks, chariots, carts, etc. Despite the indispensable role they play in the waste elimination and treatment process, the waste workers’ activity is rarely recognised and the latter are often excluded from the decisions and restructuring involved in the reform of public services that upsets their practices. Some of the traders came to the exhibition and it was a real pleasure to have them with us, together with waste pickers for the opening. There were some unexpected delays in getting the money and I had to negotiate during days with traders to get the material for free, explaining them that it was for an exhibition. It was difficult to make them understand that the South Delhi middle class people would be interested in it.

“We had asked the children to draw their parents for a series titled ‘Draw your favourite super hero’.”This exhibition seeks to focus on women and men freed from the stigma attached to waste. But it’s a world with human beings, a world with hard workers, a world full of their stories, and despite many issues and problems, it is a world full of life.Rémi de Bercegol, one of the French photographers whose works are being showcased at the exhibition, said, “Contrary to the common representation of waste workers, shown in deleterious working and living conditions, this exhibition aims to portray the world of the city of waste in a different light, wherein waste workers are freed from the stigma attached to waste. “The people were generally surprised to see a white foreign guy who can talk basic Hindi with a researcher from Karnataka interested in their business and their life

I found the ones that came packaged were the best ones for me as it offered a great, snug and comfortable fit. 1MORE calls these wings O-hooks and they help with the additional stability when seated in your ear.While the audio performance here is nothing short of great as it also supports aptX and AAC, there are a few issues which I can’t ignore. The bass output from the True Wireless had a nice, crisp punch to it while highs had sufficient amount of extension which makes for pleasant listening.The third issue I faced with them wasn’t as frequent as the first two but annoying nonetheless. If 1MORE did, in fact, add a USB Type-C port over here, chances are that the price would have shot up quite a bit. 1MORE throws in additional ear tips and ear hooks to suit different ear sizes. With that being said, there are certain other performance issues which are quite a letdown which cannot be ignored. While using these outdoors, the earbuds would intermittently lose its signal from the source. Shaped like little pebbles, they sit snug in your ear cavity without ever giving you the feeling that they will fall out. I am delighted to say that with these, there was no such sound emitted. With its Stylish series, 1MORE is offering users the opportunity to witness truly great audio and also look great flaunting their products. The first and biggest miss for me was the lack of a Type-C port.5 hours on a single charge and in my week-long testing, I found this to be pretty accurate with the volume set at about 50 per cent.Rating: 1MORE are continuously setting the standard of what quality earphones are supposed to be.Moving on, the battery life of the earbuds is rated at 6. The charging case gives you a total of 24 hours and what’s even more impressive is that it comes with fast charge. This year, the brand is implementing a new approach in a bid to reach a far wider and more discerning audience.

The egg-shaped charging case is cute and compact and that’s not it! You also get a massive 24-hours of total playback here. During my testing, the earphones performed as advertised and the recipient could hear me very clearly without any issues. If these earbuds did not have the ‘Stylish’ tag associated with it, we could cut it some slack; however, that’s just not the case.0 as well as a Qualcomm chip that offers a fast and stable connection. This anomaly was witnessed on both Android and iOS devices. While Apple’s option is a one size fits all and if they don’t it’s your loss; thankfully that’s not the case with these. If you have no problems with this and want an otherwise excellent option when it comes to audio quality, then the 1MORE Stylish True Wireless is an ideal choice for you. If only more earbuds were made like the Stylish True Wireless, they would give them 1MORE a run for its money. When removing the earphones from the charging case only one earbud would turn on. While the charging case is one of the most portable ones out there; it does have its drawbacks. I used these earbuds in a variety of environments and doing a ton of activities and they never budged even slightly..The case is spring-loaded and the only way to check on the battery is to peer at the earbuds sitting in its cradle. I don’t know why 1MORE skipped this useful and necessary feature. This is most likely due to wireless interference that’s very largely prevalent outdoors. Built entirely out of plastic, these earphones are completely lightweight which makes for comfortable listening even for prolonged periods of time. As mentioned, there’s no one size fits all, so it’s better to try on all options till you’re completely satisfied. To enable the second earbud, I had to press the single multifunction button so that they both worked.

To ensure that it paired successfully I had to enter the Bluetooth settings on my device and reconnect the earbuds.As mentioned earlier, these earbuds are extremely comfortable to use. This gets a bit annoying especially when you have to do it pretty frequently. At Rs 8,999, these are the brand’s first foray in the true wireless spectrum and looking at the spec sheet, these earbuds are completely power-packed. We found this touch of personalization quite endearing as the brand ensures that these earphones are meant for absolutely everyone.PerformanceTo start off, let me just get this out of the way — the audio quality of the 1MORE Stylish True Wireless earbuds are exemplary and based on this sole feature, it gets thrown to the top of our recommended list. The number one being connectivity which is strange since it features Bluetooth 5.The 1MORE Stylish True Wireless is priced extremely competitively in a sea that’s rapidly getting overcrowded with options spanning different price points. The basic audio performance for me depended on how great the seal was and with the ear tips and hooks that came straight out of the box; I got the best experience imaginable. However, there is a charging indicator here and when it goes off; this means that the battery is topped up.

With the new option, 1MORE doesn’t want you to merely enjoy the freedom from wires; they want you to look good doing so. However, coming with an all-plastic build, they feel a bit cheap to the touch and not premium. These earbuds come with 7mm dynamic drivers that boast a titanium composite diaphragm that helps in emitting the finer details as well as offering an above-average bass output.These earbuds come with a high-stability MEMS microphone with DSP technology that helps in cancelling out ambient noises. VerdictAvailable in four beautiful colours — Pink, Gold, Green and Black as well as being priced attractively at Rs 8,999; these make for an excellent option if attractive looking earphones with great audio quality are your thing. While the compromise does make sense, I feel keeping it future proof is much more worthwhile. Another advantage which these O-hooks provide is that they offer a seal that doesn’t allow external noises to seep in; which is effective for the most part as it helps with the overall bass response found here. These are definitely head-turners and we guarantee you if you purchase any colour apart from black you are definitely going to SP smart power Injection Molding Machine be noticed; thereby raising your style quotient greatly. It’s actually funny because 1MORE was going for an all-around ‘Stylish’ appearance and this model sadly loses out on that title. The second issue we had with it was the lack of a battery indicator.Design, BuildThe 1MORE Stylish True Wireless earbuds have a lot going for it in terms of style and build. The overall soundstage is pretty good for earphones of this type but not audiophile-grade; getting no real complaints from me.The 1MORE Stylish True Wireless is the newest model from the brand’s Stylish series and boy are these babies pretty to look at. There are true wireless earbuds available in the market at a dirt-cheap rate that offer LED battery indicators on the charging case. However, when it comes to the build quality, the plastic body put me off and what lost these earphones some of its points are the connectivity issues which can’t be ignored as you won’t get an ideal listening experience. An issue with most true wireless earbuds is that there is an audio hiss that appears because let’s face it; these form of earphones are still in its nascent stages and not as refined as traditional Bluetooth earphones. Being true wireless earphones, comparisons with market leader, Apple AirPods naturally occur.To start of this section of the review I will first talk about the audio quality. The regular stutter or loss of connection made for an unpleasant listening experience.The other issue I faced with the Stylish True Wireless earbuds was that every time I removed them from the charging case, they would not immediately connect to my smartphone. A 15-minute charge will give you as much as 3-hours of playback which is sufficient for completing most tasks such as watching a movie, finishing a gym session and other activities

A separate US National Institutes of Health-sponsored Phase II study of 159 end-stage heart failure patients dependent on an implanted pumping assist device completed enrolment in September, with results expected in the first quarter of 2018.But two small companies, Athersys Inc and Mesoblast Ltd, are beginning final stage trials in hundreds of patients that they - along with loyal investors - say could change the course of devastating stroke and heart failure.“This reinforces and cements an efficient path forward for us,” Athersys Chief Executive Gil Van Bokkelen said. S. Joseph Woo, a heart surgeon at Stanford University and an investigator of the NIH trial, “this would be considered one of the big advances of this century. Reducing the severity of a patient’s heart failure “would give them back potentially many years of good quality life,” said Mesoblast CEO Silviu Itescu.”. In the Phase II trial, Multistem patients had significantly fewer incidents of pneumonia, acute pulmonary distress and other serious complications. 

“Its reason to be cautiously optimistic,” said Dr.They are among the farthest along in the stem cell industry at a time when Wall Street investors have focused on potentially big payoffs from immune-system based cancer therapies and rare disease treatments. “Of the many entities in this field, they have been careful and deliberate in their movement forward” and do not engage in “overwrought claims,” said Dr.Athersys believes Multistem - 1.An ongoing Phase III trial of 600 advanced heart failure patients is currently enrolling.Australia’s Mesoblast, with a market value of about $500 million, is attempting to alter advanced heart failure, a leading cause of hospitalizations and deaths and an enormous cost burden.The company believes the therapy reduces inflammation, increases blood flow and spurs blood vessel formation that helps repair the heart muscle.

Cleveland-based Athersys, with a market value of about $200 million, demonstrated evidence in a mid-stage trial that its therapy may be able to expand the emergency treatment window for major strokes to up to 36 hours, compared with about four hours with current drugs, potentially allowing many more patients to avoid crippling disabilities.If such patients can recover enough to again rely on their own heart, said Dr.Both have overcome major hurdles to manufacturing stem cell treatments on a large scale that are off-the-shelf products derived from healthy donor bone marrow and do not face immune system rejection issues.Mesoblast’s MPC-150-IM therapy aims to mitigate advanced heart failure, a progressive condition in which the heart cannot pump enough blood to efficiently serve the body. A single dose consists of 150 million highly purified stem cells delivered directly to the heart’s left ventricle by injection or catheter.That trial, attempting to extend the treatment window to 48 hours, failed.Some 250,000 people in the United States alone have been diagnosed with most serious class IV heart failure, and only about 9,000 receive a transplant or left ventricular assist device (LVAD) each year, Itescu said.The body’s reaction to stroke may also severely deplete the immune system, leading to later complications beyond paralysis or speech impairment.Perception of the field has also been hurt by unscrupulous actors selling unapproved, possibly unsterile cell therapies for everything from cancer to lung disease and ALS, prompting a US crackdown this past summer.

A separate 220-patient Multistem trial in Japan for that market began enrolling patients through partner Healios KK.New York: The early hope that stem cell therapy would make the paralyzed walk, the blind see and cure diabetes have given way to a long list of failures, highlighted by early stem cell champion Geron Corp abandoning the field in 2011.Independent monitors who oversee and can halt blinded clinical trials for futility gave a green light to continue the Mesoblast study in April after a review of the first 270 treated two color injection molding machine patients, suggesting the therapy might be effective.-based M&G Investment Management that specializes in supporting promising companies during difficult periods. But researchers were encouraged by patients treated up to 36 hours post stroke. “We’re comfortable that the progress that’s going on is going to be worth it.The company plans to begin a 300-patient Phase III study of Multistem in early 2018, aiming for US and European approval after regulators agreed to protocols for one pivotal trial.K. Thomas Carmichael, co-director of UCLA Broad Stem Cell Center, who was not involved in Multistem trials.”M&G is a long-time holder of Mesoblast, with about a 15 percent stake, and Athersys, with about 4 percent.2 billion cells delivered via simple intravenous drip - dampens the immune system’s hyper-inflammatory reaction to signals that the brain is under attack during stroke, and promotes healing. “The market tends to test these companies sometimes to the brink,” said Tom Dobell, who manages a fund for U.